A respiratory disease characterized by interstitial lung disease (often with pulmonary hemorrhage) and inflammatory arthritis, associated with high-titer autoantibodies (including anti-nuclear and anti-neutrophil cytoplasmic antibodies, and rheumatoid factor). Patients present from infancy to adolescence with tachypnea, cough, hemoptysis, and/or joint pain. Some patients may also develop glomerular disease. The disease is MONDO_0014629 (autoimmune interstitial lung disease-arthritis syndrome). Also known as: COPA Syndrome, autoinflammation and autoimmunity, systemic, with immune dysregulation.