Any leukodystrophy in which the cause of the disease is a mutation in the PYCR2 gene. The disease is MONDO_0014632 (hypomyelinating leukodystrophy 10). Also known as: HLD10, PYCR2 leukodystrophy, PYCR2-related microcephaly-progressive leukoencephalopathy, hypomyelinating leukodystrophy type 10, leukodystrophy caused by mutation in PYCR2, leukodystrophy, hypomyelinating, 10, leukodystrophy, hypomyelinating, type 10.