Any CADASIL in which the cause of the disease is a mutation in the HTRA1 gene. The disease is MONDO_0014768 (cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2). Also known as: CADASIL 2, CADASIL caused by mutation in HTRA1, CADASIL type 2, CADASIL2, HTRA1 CADASIL, autosomal dominant cerebral arteriopathy with subcortical infarcts and leukoencephalopathy type 2.