Any mitochondrial DNA depletion syndrome in which the cause of the disease is a mutation in the OPA1 gene. The disease is mitochondrial DNA depletion syndrome 14 (cardioencephalomyopathic type) (MONDO_0014820). Also known as: MTDPS14, OPA1 mitochondrial DNA depletion syndrome, mitochondrial DNA depletion syndrome 14 (cardioencephalomyopathic type); MTDPS14, mitochondrial DNA depletion syndrome 14 (encephalocardiomyopathic type), mitochondrial DNA depletion syndrome caused by mutation in OPA1.