An autosomal recessive sub-type of Charcot-Marie-Tooth disease caused by compound heterozygous or homozygous mutation(s) in the MFN2 gene, encoding mitofusin-2. This condition is more severe and has an earlier onset as compared to Charcot-Marie-Tooth disease type 2A2A. The disease is Charcot-Marie-Tooth disease, axonal, autosomal recessive, type 2a2b; (MONDO_0014906). Also known as: Charcot-Marie-Tooth disease type 2A2B, Charcot-Marie-Tooth disease, axonal, type 2A2B.