Any peeling skin syndrome in which the cause of the disease is a mutation in the SERPINB8 gene. The disease is Monarch Disease Ontology entry MONDO_0014923 (peeling skin syndrome 5). Also known as: PSS5, SERPINB8 peeling skin syndrome, peeling skin syndrome 5; PSS5, peeling skin syndrome caused by mutation in SERPINB8, peeling skin syndrome type 5.