MONDO_0015250 (spinal atrophy-ophthalmoplegia-pyramidal syndrome) is a rare, bulbospinal muscular atrophy characterized by generalized neonatal hypotonia, progressive pontobulbar and spinal palsy, pyramidal signs, and deafness. External ophthalmoplegia and bilateral mydriasis are typical signs. There have been no further descriptions in the literature since 1994. Also known as: Hamano-Tsukamoto syndrome.