Cardiofaciocutaneous (CFC) syndrome is a RASopathy characterized by craniofacial dysmorphology, congenital heart disease, dermatological abnormalities (most commonly hyperkeratotic skin and sparse, curly hair), growth retardation and intellectual disability. The disease is MONDO_0015280 (cardiofaciocutaneous syndrome). Also known as: CFC, CFC syndrome, cardio-facial-cutaneous syndrome, cardiofaciocutaneous (CFC) syndrome.