MONDO_0015516 (symbrachydactyly of hands and feet) is a rare, non-syndromic limb reduction defect disorder characterized by unilateral or bilateral brachydactyly, cutaneous syndactyly and global hypoplasia of the hand and/or foot, with underlying muscles, tendons, ligaments and bones being affected but without other associated limb anomalies. Patients typically present short, stiff, webbed or missing fingers and/or toes which are often replaced with small stumps (nubbins) with residual nails. Also known as: De Smet-Fabry-Fryns syndrome, frints de Smet Fabry Fryns syndrome, symbrachydactyly of the hand and foot.