Castleman disease (CD) is a benign lymphoproliferative disorder that may present as a localized or multicentric form. The clinical manifestations are heterogeneous, ranging from asymptomatic discrete lymphadenopathy to recurrent episodes of diffuse lymphadenopathy with severe systemic symptoms. The disease is Monarch Disease Ontology entry MONDO_0015564 (Castleman disease). Also known as: AFLH, Castleman's disease, Castleman's tumor, Castleman's tumour, GLNH, angiofollicular ganglionic hyperplasia, angiofollicular lymph hyperplasia, angiofollicular lymph node hyperplasia.