A rare, malignant, neoplastic disease characterized by clonal proliferation of myeloid and/or lymphoid precursors harboring rearrangements in the PDGFRB gene, in the blood, bone marrow and often other tissues as well (spleen, lymph nodes, skin, etc.). It usually presents as chronic myelomonocytic leukemia with eosinophilia, chronic eosinophilic leukemia, atypical chronic myelogenous leukemia, juvenile myelomonocytic leukemia, myelodysplastic syndrome, acute myeloid leukemia or acute lymphoblastic leukemia. Patients usually present with anemia, leukocytosis, monocytosis, eosinophilia and/or splenomegaly, or systemic symptoms, such as fever, sweating and/or weight loss. The disease is MONDO_0015690 (myeloid neoplasm associated with PDGFRB rearrangement). Also known as: myeloid and lymphoid neoplasms with PDGFRB rearrangement, myeloid neoplasms associated with PDGFRB rearrangement, myeloid neoplasms with PDGFRB rearrangement, myeloid/lymphoid neoplasms with PDGFRB rearrangement.