Melorheostosis with osteopoikilosis is a rare sclerosing bone dysplasia, combining the clinical and radiological features of melorheostosis and osteopoikilosis, that has been reported in some families with osteopoikilosis and that is characterized by a variable presentation of limb pain and deformities. The disease is melorheostosis with osteopoikilosis (MONDO_0015995). Also known as: MSBD syndrome, mixed sclerosing bone dystrophy.