mucopolysaccharidosis type 2, severe form (MONDO_0016315) can be described as follows. Mucopolysaccharidosis type 2 (MPS2), severe form (MPS2S), is associated with a massive accumulation of glycosaminoglycans and a wide variety of symptoms including a rapidly progressive cognitive decline; it is most often fatal in the second or third decade. Also known as: Hunter syndrome type A, MPS2A, MPSIIA, iduronate 2-sulfatase deficiency type A, mucopolysaccharidosis type 2A, mucopolysaccharidosis type II, severe form, mucopolysaccharidosis type IIA.