Hydrocephalus-blue sclera-nephropathy syndrome is a rare, genetic, renal or urinary tract malformation syndrome characterized by nephrotic syndrome with focal segmental sclerosis associated with hydrocephalus, thin skin and blue sclerae. There have been no further descriptions in the literature since 1978. The disease is MONDO_0016350 (hydrocephalus-blue sclerae-nephropathy syndrome). Also known as: Daentl-Townsend-Siegel syndrome, familial nephrosis, hydrocephalus, thin skin, blue sclerae syndrome, hydrocephalus blue sclera nephropathy.