Isolated agammaglobulinemia (IA) is the non-syndromic form of agammaglobulinemia, a primary immunodeficiency disease, and is characterized by deficient gamma globulins and associated predisposition to frequent and recurrent infections from infancy. The disease is MONDO_0016462 (isolated agammaglobulinemia). Also known as: isolated hypogammaglobulinemia, nonsyndromic agammaglobulinemia.