MONDO_0016491 (hemoglobin E-beta-thalassemia syndrome) can be described as follows. Hemoglobin E - beta-thalassemia (HbE - BT) is a form of beta-thalassemia that results in a mild to severe clinical presentation ranging from a condition indistinguishable from beta-thalassemia major to a mild form of beta-thalassemia intermedia. Also known as: E-beta-thalassemia, HbE-beta-thalassemia syndrome.