Monarch Disease Ontology id MONDO_0016584 (mandibuloacral dysplasia) (MAD) is a rare genetic bone disorder characterized by growth delay, postnatal development of craniofacial anomalies including mandibular hypoplasia, progressive acral osteolysis, mottled or patchy pigmentation, skin atrophy, and partial or generalized lipodystrophy. Also known as: MAD, mandibuloacral dysplasia with lipodystrophy.