yolk sac tumor of central nervous system (MONDO_0016739) is a malignant germ cell tumor of the central nervous system composed of primitive-appearing epithelial cells - putatively representing yolk sac endoderm - set in a loose, variably cellular, and often conspicuously myxoid matrix, resembling extra-embryonic mesoblast. Eosinophilic hyaline globules immunoreactive for AFP are a diagnostic feature. (WHO). Also known as: CNS yolk Sac tumor, CNS yolk Sac tumour, central nervous system yolk Sac tumor, central nervous system yolk Sac tumour, endodermal sinus tumor of CNS, endodermal sinus tumor of central nervous system, endodermal sinus tumour of CNS, endodermal sinus tumour of central nervous system.