primary melanoma of the central nervous system (MONDO_0016747) can be described as follows. A melanoma that affects the central nervous system. It is characterized by pleomorphism, melanin pigmentation, a high mitotic rate, necrosis, and hemorrhage. It is a highly aggressive and radioresistant tumor. The prognosis is usually poor. Also known as: CNS melanoma, Central nervous system melanoma, central nervous system melanoma, central nervous system melanoma (disease), melanoma (disease) of central nervous system, melanoma of CNS, melanoma of central nervous system, melanoma of the CNS.