A group of diverse conditions that are characterized by spontaneous, multi-organ autoimmunity, which target both endocrine (adrenal, gonad, pancreatic islet cells, parathyroid, pituitary, thyroid) and non-endocrine (gastrointestinal, integumentary, lymphatic) tissues. The disease is MONDO_0017278 (autoimmune polyendocrinopathy). Also known as: APS, Antiphospholipid Syndrome, Lloyd's syndrome, autoimmune polyendocrine syndrome, autoimmune polyendocrine syndrome; polyglandular autoimmune syndrome, autoimmune polyendocrinopathy syndrome, autoimmune polyglandular failure, autoimmune polyglandular syndrome.