Neoplasm predisposition characterized by an increased risk of paragangliomas (tumors that arise from neuroendocrine tissues distributed along the paravertebral axis from the base of the skull to the pelvis) and pheochromocytomas (paragangliomas that are confined to the adrenal medulla). The disease is Monarch Disease Ontology term MONDO_0017366 (hereditary pheochromocytoma-paraganglioma). Also known as: familial pheochromocytoma-paraganglioma, hereditary paraganglioma-pheochromocytoma syndrome.