A carcinoma arising from the ampulla of Vater. The vast majority of cases are adenocarcinomas. Signs and symptoms include jaundice, abdominal pain, anorexia, nausea, vomiting, and weight loss. The disease is Monarch Disease Ontology term MONDO_0017590 (carcinoma of the ampulla of vater). Also known as: Ampulloma, ampulla of Vater cancer, ampulla of Vater carcinoma, ampullary cancer, ampullary carcinoma, carcinoma of ampulla of vater, carcinoma of hepatopancreatic ampulla, hepatopancreatic ampulla carcinoma.