Combined deficiency of factor V and factor VIII is an inherited bleeding disorder due to the reduction in activity and antigen levels of both factor V (FV) and factor VIII (FVIII) and characterized by mild-to-moderate bleeding symptoms. The disease is MONDO_0018175 (combined deficiency of factor V and factor VIII). Also known as: F5F8D, FV and FVIII combined deficiency, combined deficiency of factor V and factor type VIII, familial multiple coagulation factor deficiency.