Monarch Disease Ontology entry MONDO_0018280 (muscle-eye-brain disease with bilateral multicystic leucodystrophy) can be described as follows. Muscle-eye-brain (MEB) disease with bilateral multicystic leucodystrophy is a form of congenital muscular alpha-dystroglycanopathy with brain and eye anomaly characterized by severe muscle-eye-brain disease-like phenotype associated with macrocephaly and extended bilateral multicystic white matter disease, overlapping with the cerebral findings in patients with megalencephalic leukoencephalopathy with subcortical cysts. Also known as: MEB disease with bilateral multicystic leucodystrophy.