A rare genetic chronic skeletal disorder characterized by peripheral osteolysis (especially carpal and tarsal bones), interphalangeal joint erosions, subcutaneous fibrocollagenous nodules, facial dysmorphism, and a wide range of associated manifestations. The disease is multicentric osteolysis-nodulosis-arthropathy spectrum (MONDO_0018298, a Monarch Disease Ontology entry). Also known as: MONA spectrum.