A chronic, autoimmune inflammatory liver disorder characterized by narrowing and scarring of the lumen of the bile ducts. It is often seen in patients with ulcerative colitis. Signs and symptoms include jaundice, fatigue, and malabsorption. It may lead to cirrhosis and liver failure. The disease is MONDO_0018646 (sclerosing cholangitis). Also known as: Primary sclerosing cholangitis, fibrosing cholangitis, primary sclerosing cholangitis (PSC), sclerosing cholangitis (disease).