Monarch Disease Ontology id MONDO_0018865 (striate palmoplantar keratoderma) is an isolated, focal, hereditary palmoplantar keratoderma characterized by linear hyperkeratosis along the flexor aspect of the fingers and on palms, as well as focal hyperkeratosis of the plantar skin. Patients present with painful thickening of the skin on palms and soles, with occasional fissuring, blistering and hyperhidrosis. Rarely, hyperkeratosis on other areas may be seen (knees, dorsal aspects of the digits). Histopatologically, widened intercellular spaces between keratinocytes are observed. Also known as: keratosis palmoplantaris striata, keratosis palmoplantaris striata et areata, keratosis palmoplantaris varians of Wachters.