MONDO_0018872 (acute megakaryoblastic leukemia) (AMKL) is a form of acute myeloid leukemia (AML) that occurs predominantly in childhood and particularly in children with Down syndrome (DS-AMKL). Nonspecific symptoms may be irritability, weakness, and dizziness while specific symptoms include pallor, fever, mucocutaneous bleeding, hepatosplenomegaly, neurological manifestations and rarely lymphadenopathy. Acute panmyelosis with myelofibrosis may also be associated with AMKL. In contrast to DS-AMKL (around 80 % survival), non-DS-AMKL is an AML subgroup associated with poor prognosis. Also known as: AMKL, AML M7, FAB M7, acute M7 myeloid leukaemia, acute M7 myeloid leukemia, acute megakaryoblastic leukaemia (FAB type M7), acute megakaryoblastic leukemia (FAB type M7), acute megakaryoblastic leukemia, FAB M7.