An autosomal dominant cancer predisposition disorder caused by pathogenic variants in the TP53 gene, characterized by an increased risk of a wide range of cancers, including but not limited to breast cancer, soft tissue sarcomas, osteosarcomas, brain tumors, adrenocortical carcinoma and leukemias. The disease is Li-Fraumeni syndrome (Monarch Disease Ontology id MONDO_0018875). Also known as: LFS, Li Fraumeni syndrome, Li-Fraumeni familial cancer susceptibility syndrome, Li-Fraumeni familiar cancer susceptibility syndrome, Li-Fraumeni syndrome caused by mutation in TP53, SBLA syndrome, TP53 Li-Fraumeni syndrome, TP53-related Li-Fraumeni syndrome.