Monarch Disease Ontology entry MONDO_0018999 (LCAT deficiency) can be described as follows. LCAT (lecithin-cholesterol acyltransferase) deficiency is a rare lipoprotein metabolism disorder characterized clinically by corneal opacities, and sometimes renal failure and hemolytic anemia, and biochemically by severely reduced HDL cholesterol. Also known as: lecithin-cholesterol acyltransferase deficiency.