Hereditary spastic paraplegias (HSP) comprise a genetically and clinically heterogeneous group of neurodegenerative disorders characterized by progressive spasticity and hyperreflexia of the lower limbs. The disease is MONDO_0019064 (hereditary spastic paraplegia). Also known as: French settlement disease, HSP, SPG, Strumpell-Lorrain disease, Strümpell-Lorrain disease, familial spastic paraplegia, hereditary spastic paraparesis.