Interstitial 9q22.3 microdeletion is associated with a phenotype including macrocephaly, overgrowth and trigonocephaly. Psychomotor delay, hyperactivity and distinctive facial features were also observed. It has been described in two unrelated children. The disease is monosomy 9q22.3 (MONDO_0019179). Also known as: microdeletion 9q22.3.