Monarch Disease Ontology entry MONDO_0019193 (acquired generalized lipodystrophy) belongs to a group of lipodystrophic syndromes characterized by loss of adipose tissue, and is a syndrome of insulin resistance that leads to increased cardiovascular risk. Acquired generalized lipodystrophy is related to a selective loss of subcutaneous adipose tissue occurring exclusively at the extremities (face, legs, arms, palms and sometimes soles). Also known as: Lawrence syndrome, Lawrence-Seip syndrome, acquired lipoatrophic diabetes.