Punctate palmoplantar keratoderma type I (PPKP1), also known as Buschke-Fischer-Brauer syndrome, is a very rare hereditary skin disease characterized by irregularly distributed epidermal hyperkeratosis of the palms and soles with wide variation among patients.. The disease is MONDO_0019332 (punctate palmoplantar keratoderma type 1). Also known as: Buschke-Fischer-Brauer syndrome, PPKP1, keratodermia palmoplantaris papulosa, Buschke-Fischer-Brauer type.