Antisynthetase (AS) syndrome is a clinically heterogeneous form of idiopathic inflammatory myopathy characterized by myositis, arthralgia, Raynaud phenomenon, mechanic hands, interstitial lung disease (ILD), and serum autoantibodies to aminoacyl transfer RNA synthetases (anti-ARS). The disease is antisynthetase syndrome (Monarch Disease Ontology term MONDO_0019344). Also known as: AS syndrome, anti-Jo1 syndrome.