Sotos syndrome (MONDO_0019349, a Monarch Disease Ontology identifier) is a rare multisystemic genetic disorder characterized by a typical facial appearance, overgrowth of the body in early life with macrocephaly, and mild to severe intellectual disability. Also known as: NSD1 Sotos syndrome, Sotos syndrome 1, Sotos syndrome caused by mutation in NSD1, Sotos syndrome type 1, Sotos' syndrome, cerebral gigantism, cerebral gigantism syndrome, chromosome 5q35 deletion syndrome.