X-linked intellectual disability-corpus callosum agenesis-spastic quadriparesis syndrome is characterized by intellectual and motor deficit, spastic quadriparesis and agenesis of the corpus callosum, without craniofacial abnormalities or seizures. It has been described in four male members of a family. The mode of inheritance is most likely X-linked recessive. The disease is X-linked intellectual disability-corpus callosum agenesis-spastic quadriparesis syndrome (MONDO_0019426, a Monarch Disease Ontology entry).