acute myeloid leukemia with multilineage dysplasia (MONDO_0019456, a Monarch Disease Ontology entry) is an acute myeloid leukemia arising de novo and not as a result of treatment. It is characterized by the presence of myelodysplastic features in at least 50% of the cells of at least two hematopoietic cell lines. Patients often present with severe cytopenia. Also known as: AML with multilineage dysplasia, AML with myelodysplasia-related features, De novo acute myeloid leukaemia with multilineage dysplasia, De novo acute myeloid leukemia with multilineage dysplasia.