Splenic marginal zone lymphoma is a rare, indolent B-cell non-Hodgkin lymphoma characterized by abnormal clonal proliferation of mature B-lymphocytes with involvement in the spleen, bone marrow and, frequently, the blood. It usually presents with splenomegaly, lymphocytosis, anemia and/or thrombocytopenia. Hepatitis C virus and autoimmune manifestations, such as autoimmune hemolytic anemia and autoimmune thrombocytopenia, could be associated. The disease is splenic marginal zone lymphoma (MONDO_0019462). Also known as: SLVL, SMZL, marginal zone lymphoma of spleen, marginal zone lymphoma of the spleen, splenic lymphoma with circulating villous lymphocytes, splenic marginal zone B-cell lymphoma, splenic marginal zone B-cell lymphoma with villous lymphocytes, splenic marginal zone lymphoma with villous lymphocytes.