The most severe variant seen in the peroxisome biogenesis disorders that is characterized by neuronal migration defects in the brain, dysmorphic craniofacial features, profound hypotonia, neonatal seizures, and liver dysfunction. The disease is MONDO_0019609 (Zellweger spectrum disorders). Also known as: ZS, ZWS, Zellweger syndrome, cerebrohepatorenal syndrome, congenital iron overload.