Severe-immune mediated enteropathy describes a variety of intestinal disorders that can range from a serious, early-onset systemic disease (IPEX) to a mild isolated gastrointestinal disease. In children it manifests with severe diarrhea and dehydration in the presence of characteristic antibodies (anti-enterocyte and anti-goblet cell) and in adults with chronic diarrhea, malabsorption and weight loss. The disease is Monarch Disease Ontology identifier MONDO_0019787 (autoimmune enteropathy). Also known as: immune-mediated protracted diarrhea of infancy, immune-mediated protracted diarrhoea of infancy, severe immune-mediated enteropathy.