Pituitary stalk interruption syndrome (PSIS) is a congenital abnormality of the pituitary that is responsible for pituitary deficiency and is usually characterized by the triad of a very thin or interrupted pituitary stalk, an ectopic (or absent) posterior pituitary (EPP) and hypoplasia or aplasia of the anterior pituitary visible on MRI. In some patients the abnormality may be limited to EPP (also called ectopic neurohypophysis) or to an interrupted pituitary stalk. The disease is pituitary stalk interruption syndrome (Monarch Disease Ontology entry MONDO_0019828). Also known as: PSIS, ectopic neurohypophysis, hypoplastic anterior pituitary, missing stalk, and ectopic posterior pituitary.