ACTH-independent macronodular adrenal hyperplasia 1 (MONDO_0020735) is any Cushing syndrome due to macronodular adrenal hyperplasia in which the cause of the disease is a mutation in the GNAS1 gene. Also known as: ACTH-independent macronodular adrenal hyperplasia, Somatic mutation, ACTH-independent macronodular adrenocortical hyperplasia, AIMAH1, Cushing syndrome, adrenal, due to AIMAH, adrenocorticotropic hormone-independent macronodular adrenal hyperplasia, corticotropin-independent macronodular adrenal hyperplasia.