Disorders caused by imbalances in the protein homeostasis network - synthesis, folding, and transport of proteins; post-translational modifications; and degradation or clearance of misfolded proteins. The disease is proteostasis deficiencies (Monarch Disease Ontology id MONDO_0021179). Also known as: Proteostasis deficiency, Proteostasis dysfunction, Proteostasis dysfunctions, deficiencies, Proteostasis, deficiency, Proteostasis, dysfunction, Proteostasis, dysfunctions, Proteostasis.