MONDO_0024609 (vulvar squamous cell carcinoma) is an invasive squamous cell carcinoma arising from the vulva. Risk factors include the human papilloma virus and cigarette smoking. Precursor lesions include the vulvar intraepithelial neoplasia, lichen sclerosus with associated squamous cell hyperplasia, and chronic granulomatous vulvar disease such as granuloma inguinale. Symptoms include vulvar pruritus or irritation, discharge, bleeding, and pain. The following morphologic variants have been identified: keratinizing, non-keratinizing, basaloid, warty, verrucous, keratoacanthoma-like, and squamous cell carcinoma with tumor giant cells. Risk factors for recurrence include advanced stage, tumor diameter greater than 2.5 cm, multifocality, capillary-like space involvement, associated vulvar intraepithelial neoplasia grades 2 or 3, and margins of resection involved by tumor. (WHO, 2003). Also known as: epidermoid carcinoma of the vulva, epidermoid carcinoma of vulva, epidermoid cell carcinoma of the vulva, epidermoid cell carcinoma of vulva, mammalian vulva squamous cell carcinoma, squamous cell carcinoma of the vulva, squamous cell carcinoma of vulva, vulva epidermoid carcinoma.