An X-linked recessive immunologic disorder characterized by the onset of recurrent sinopulmonary, mucosal, and other infections in early childhood, usually accompanied by refractory autoimmune cytopenias. Affected individuals have bacterial, viral, and fungal infections, as well as hemolytic anemia, thrombocytopenia, lymphopenia, and decreased NK cells. Laboratory studies show defective T-cell proliferation and function, likely due to signaling abnormalities. The disorder may also manifest as a hyperinflammatory state with immune dysregulation. The disease is Monarch Disease Ontology identifier MONDO_0024781 (immunodeficiency 102). Also known as: IMD102, SASH3 deficiency, X-linked CID due to SASH3 deficiency, X-linked combined immunodeficiency due to SASH3 deficiency.