MONDO_0030491 (immunodeficiency 91 and hyperinflammation) is an autosomal recessive immunodeficiency caused by a variation in the ZNFX1 gene, characterized by severe infections by both RNA and DNA viruses and virally triggered inflammatory episodes with hemophagocytic lymphohistiocytosis-like disease, early-onset seizures, and renal and lung disease. Also known as: IMD91, immunodeficiency, autosomal recessive, due to ZNFX1 deficiency:.