MONDO_0031421 (Olmsted syndrome) is a hereditary palmoplantar keratoderma characterized by the combination of bilateral mutilating transgredient palmoplantar keratoderma and periorificial keratotic plaques. Also known as: mutilating palmoplantar hyperkeratosis with periorificial keratotic plaques, palmoplantar and periorificial keratoderma, palmoplantar keratoderma, mutilating, with periorificial keratotic plaques.