A severe, sometimes life-threatening, form of erythema multiforme. It is considered to be a hypersensitivity skin reaction triggered by a variety of stimuli, including infections and medication. It is characterized by raised, edematous papules in the extremities; involvement of one or more mucous membranes; and epidermal detachment involving less than ten percent of the total body surface area. The disease is MONDO_0044719 (erythema multiforme major). Also known as: erythema exsudativum multiforme majus, erythema multiforme majus.