Monarch Disease Ontology entry MONDO_0100061 (PRPS1 deficiency disorder) can be described as follows. A peripheral neuropathy that is characterized by variants in PRPS1, which causes decreased or impaired function of the PRPS1 enzyme, and presents as a range of peripheral neuropathies that can include features of Charcot-Marie Tooth syndrome, Arts syndrome, or nonsyndromic hearing loss. Also known as: PRPS1-related CMTX5/Arts syndrome/XLNSHL.